GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11799420 | 1 | rs10913514 | chr1:171670823 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.28 | 1.59E-7 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs10913529 | chr1:171679465 | VAMP4 | chr1:171669298-171711214:- | 0.21 | 6.26 | 5.68E-10 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs10913565 | chr1:171706706 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.47 | 5.76E-8 | Hippocampal atrophy |
| BRCA | cis | rs4654899 | 1 | rs10916921 | chr1:21334542 | HP1BP3 | chr1:21069171-21113799:- | 0.12 | 3.6 | 0.000337 | Superior frontal gyrus grey matter volume |
| BRCA | cis | rs4654899 | 1 | rs10916921 | chr1:21334542 | SH2D5 | chr1:21046225-21059330:- | 0.13 | 3.49 | 0.000505 | Superior frontal gyrus grey matter volume |
| BRCA | cis | rs6697139 | 1 | rs10917686 | chr1:161658490 | FCGR2B | chr1:161632940-161647951:+ | -0.15 | -4.29 | 1.92E-5 | Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis |
| BRCA | cis | rs6697139 | 1 | rs10917688 | chr1:161658780 | FCGR2B | chr1:161632940-161647951:+ | 0.14 | 4.08 | 4.79E-5 | Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis |
| BRCA | cis | rs1092015 | 1 | rs1092015 | chr14:58200725 | EXOC5 | chr14:57669196-57735617:- | -0.18 | -3.59 | 0.000344 | Bipolar disorder and schizophrenia |
| BRCA | cis | rs1092015 | 1 | rs1092015 | chr14:58200725 | PSMA3 | chr14:58711593-58738726:+ | -0.18 | -3.53 | 0.000432 | Bipolar disorder and schizophrenia |
| BRCA | cis | rs10927875 | 1 | rs10927875 | chr1:16299312 | CLCNKA | chr1:16345370-16360544:+ | 0.2 | 5.31 | 1.31E-7 | Dilated cardiomyopathy |
| BRCA | cis | rs4664308 | 1 | rs10929965 | chr2:160906931 | LY75 | chr2:160625141-160761262:- | -0.14 | -4.72 | 2.62E-6 | Idiopathic membranous nephropathy |
| BRCA | cis | rs4664308 | 1 | rs10929965 | chr2:160906931 | PLA2R1 | chr2:160798012-160919121:- | -0.15 | -5.14 | 3.31E-7 | Idiopathic membranous nephropathy |
| BRCA | cis | rs4664308 | 1 | rs10929966 | chr2:160908341 | LY75 | chr2:160625141-160761262:- | 0.14 | 4.81 | 1.75E-6 | Idiopathic membranous nephropathy |
| BRCA | cis | rs4664308 | 1 | rs10929966 | chr2:160908341 | PLA2R1 | chr2:160798012-160919121:- | 0.15 | 5.11 | 3.85E-7 | Idiopathic membranous nephropathy |
| BRCA | cis | rs4675374 | 1 | rs10932031 | chr2:204804494 | CD28 | chr2:204571198-204602556:+ | 0.09 | 3.73 | 0.000205 | Celiac disease |